UK’s NICE Publishes a Medtech Innovation Briefing on PICO™ for the Prophylactic Use in Surgically Closed Incisions to Reduce Surgical Site Complications

LONDON and NEW YORK, July 3, 2018 /PRNewswire/ —

Smith & Nephew (LSE: SN) (NYSE: SNN), the global medical technology business, announces that the UK’s National Institute for Health and Care Excellence (NICE) has issued a Medtech innovation briefing (MIB) on the use of PICO Single Use Negative Pressure Wound Therapy (sNPWT).

The MIB reports the prophylactic use of PICO as a potentially more effective alternative to standard surgical dressings in the prevention of surgical site complications (SSCs). This is the first and only MIB published by NICE on an NPWT device for preventing SSCs.

Complications from surgical incisions are a significant economic and human burden, costing an approximate £1 billion[1] to the NHS each year and contributing to significant morbidity and mortality in the UK and globally. A recent World Union of Wound Healing Societies consensus guidelines reports that up to 60% of surgical site infections (SSIs) are preventable[2].

The prophylactic use of the PICO system is proven to be effective in reducing SSCs, including SSIs and dehiscence (wound rupturing) of the surgical incision, in patients at elevated risk of SSCs[7].

The PICO dressing has a proprietary AIRLOCK™ Technology that uniformly and consistently delivers NPWT across a surgical incision and the surrounding zone of injury generated naturally by the incision itself[3],[4]. This proprietary feature is designed to help reduce the risk of wound complications by reducing post-operative fluid, swelling and associated tension around a closed surgical incision compared with standard dressings[5],[6]. The combination of these actions helps reduce the risk of surgical wound dehiscence[7] and SSIs[7], the 2 most common SSCs.

Evidence shows how the prophylactic use of PICO resulted in fewer complications, and in earlier discharge from hospitals, reducing length of stay, on average by more than 8 days, in closed laparotomy wounds after abdominal surgery[8]*, which has the potential to release bed days for the NHS. In patients undergoing primary hip and knee arthroplasties, it was estimated that care with PICO enabled cost savings of more than £7,000 per high-risk patient (BMI ≥35 or ASA ≥3) compared with care with standard dressings[9]**.

Read more about NICE’s finding here: http://www.smith-nephew.com/PICOMIB

Ms Pauline Whitehouse, Consultant General and Colorectal Surgeon, Worthing Hospital, said, “Following the introduction of PICO into our Trust for moderate- to high-risk incisions, we quickly noticed a significant reduction in superficial surgical site infections. We have now introduced PICO across the Trust and are seeing similar reductions in infective complications for other specialities.”

MIBs are objective information on device and diagnostic technologies to aid local decision-making by clinicians, managers and procurement professionals. They are NICE advice, designed to support NHS and social care commissioners and staff who are considering using new medical devices, and other medical or diagnostic technologies. The briefing will help avoid the need for organisations to produce similar information locally, saving staff time and resources. MIBs are commissioned by NHS England and produced in support of the NHS 5-Year Forward View, specifically as one of a number of steps that will accelerate innovation in new treatments and diagnostics.

As part of the MIB, NICE conducted a thorough review of the published and peer-reviewed data from a variety of meta-analyses and randomised controlled trials (RCTs). The effectiveness of PICO in reducing SSCs has been examined in 10 RCTs and multiple observational studies. A recently published 1,839 patient meta-analysis demonstrated the efficacy of PICO, used prophylactically, significantly reducing SSIs by 58% in closed surgical incisions compared with standard care[5]***.

PICO is suitable for use in both hospital and community settings, and is approved for a number of indications, including surgically closed incision sites.

“NICE MIBs are a great resource for NHS organisations, and are often a reference used by healthcare systems beyond the UK. Today we are delighted to see the NICE MIB support for the prophylactic use of PICO as an effective alternative for clinicians who look to reduce their rates of surgical site complications. This will provide them with the confidence to use PICO for their at-risk patients and procedures, in support of their efforts to achieve better economic and clinical outcomes,” said Paolo Di Vincenzo, Smith & Nephew’s SVP of Advanced Wound Management. “With PICO, we are keeping Smith & Nephew at the forefront of delivering pioneering solutions that continue to improve current standards of care, by reducing the burden and delivering better clinical and economic outcomes. PICO has shown significant clinical results in reducing life-threatening infections on closed surgical incisions, which has contributed significantly to improved patient outcomes, in a cost-effective portable solution.”

About Smith & Nephew 

Smith & Nephew is a global medical technology business dedicated to helping healthcare professionals improve people’s lives. With leadership positions in Orthopaedic Reconstruction, Advanced Wound Management, Sports Medicine and Trauma & Extremities, Smith & Nephew has around 15,000 employees and a presence in more than 100 countries. Annual sales in 2017 were almost $4.8 billion. Smith & Nephew is a member of the FTSE100 (LSE:SN, NYSE:SNN).

For more information about Smith & Nephew, please visit our website http://www.smith-nephew.com, follow @SmithNephewplc on Twitter or visit SmithNephewplc on Facebook.com.

Forward-looking Statements 

This document may contain forward-looking statements that may or may not prove accurate. For example, statements regarding expected revenue growth and trading margins, market trends and our product pipeline are forward-looking statements. Phrases such as “aim”, “plan”, “intend”, “anticipate”, “well-placed”, “believe”, “estimate”, “expect”, “target”, “consider” and similar expressions are generally intended to identify forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other important factors that could cause actual results to differ materially from what is expressed or implied by the statements. For Smith & Nephew, these factors include: economic and financial conditions in the markets we serve, especially those affecting health care providers, payers and customers; price levels for established and innovative medical devices; developments in medical technology; regulatory approvals, reimbursement decisions or other government actions; product defects or recalls or other problems with quality management systems or failure to comply with related regulations; litigation relating to patent or other claims; legal compliance risks and related investigative, remedial or enforcement actions; disruption to our supply chain or operations or those of our suppliers; competition for qualified personnel; strategic actions, including acquisitions and dispositions, our success in performing due diligence, valuing and integrating acquired businesses; disruption that may result from transactions or other changes we make in our business plans or organisation to adapt to market developments; and numerous other matters that affect us or our markets, including those of a political, economic, business, competitive or reputational nature. Please refer to the documents that Smith & Nephew has filed with the U.S. Securities and Exchange Commission under the U.S. Securities Exchange Act of 1934, as amended, including Smith & Nephew’s most recent annual report on Form 20-F, for a discussion of certain of these factors. Any forward-looking statement is based on information available to Smith & Nephew as of the date of the statement. All written or oral forward-looking statements attributable to Smith & Nephew are qualified by this caution. Smith & Nephew does not undertake any obligation to update or revise any forward-looking statement to reflect any change in circumstances or in Smith & Nephew’s expectations. 

(TM) Trademark of Smith & Nephew.  Certain marks registered US Patent and Trademark Office.  

* 50-patient study; length of stay reduced: PICO 6.1 days; control group 14.7 days; p<0.019

** Calculations based on a 220-patient RCT

*** Meta-analysis included 10 RCT and 6 observational studies. Reduction in SSI (16 studies) included 1,839 patients (2,154 incisions); PICO 5.2%; control group 12.5%; p<0.0001. Mean reduction in hospital length of stay (8 studies included): 0.47 days; p<0.0001

References: 

1. Guest J et al, Health economic burden that different wound types impose on the UK’s National Health Service. Int Wound J 2016; doi: 10.1111/iwj.12603

2. World Union of Wound Healing Societies (WUWHS) Consensus Document. Closed surgical incision management: understanding the role of NPWT. Wounds International, 2016

3. Data on File. DS/17/253/R. Project Opal PICO 7 System Stability Testing – Initial Time Point. October 2017

4. Malmsjö M et al. Biological effects of a disposable, canisterless Negative Pressure Wound Therapy system (in-vitro). Eplasty 2014; 14:e15

5. Selvaggi F et al., New Advances in Negative Pressure Wound Therapy (NPWT) for Surgical Wounds of Patients Affected with Crohn’s Disease. Surgical Technology International XXIV; 83- 89

6. Loveluck et al (2016) Biomechanical modeling of forces applied to closed incision during NPWT eplasty16e20

7. Strugala, V. and Martin, R. Meta-analysis of comparative trials evaluating a prophylactic single-use negative pressure wound therapy system for the prevention of surgical site complications. Surgical Infections (2017). DOI 10.1089/sur.2017.156

8. O’Leary, Donal Peter et al. 2017. “Prophylactic Negative Pressure Dressing Use in Closed Laparotomy Wounds Following Abdominal Operations.” Annals of Surgery. Jun 265(6): 1082-1086

9. Nherera LM, Trueman P, Karlakki SL. Cost-effectiveness analysis of single-use negative pressure wound therapy dressings (sNPWT) to reduce surgical site complications (SSC) in routine primary hip and knee replacements. Wound Repair Regen. April 2017. doi:10.1111/wrr.12530

PDF: https://mma.prnewswire.com/media/713194/PICO_Single_Use_Negative_Pressure_Wound_Therapy.pdf

Honorary Trustee Appointment Ceremony for Dr. Lui Che-woo and “LUI Che Woo Prize” Symposium Held at Peking University

-Teachers and students exchange views on “Facing the World: The Role, Opportunities and Challenges of Promoting Sustainable Development in China”

-Dr. Mo Yan, member of the Prize Recommendation Committee, and Mr. Xie Zhenhua, laureate of the 2017 Award, serve as speakers

BEIJING, July 3, 2018 /PRNewswire/ — The Honorary Trustee Appointment Ceremony for Dr. Lui Che Woo and the “LUI Che Woo Prize” symposium were held Friday at Yingjie Exchange Center, Peking University. Dr. Lui Che-woo, founder of the “LUI Che Woo Prize  Prize for World Civilisation”, Prof. Lin Jianhua, President of Peking University, Prof. XU Guanhua, Former Minister of the Ministry of Science and Technology, Selection Panel Member of the Sustainability Prize, Mr. Xie Zhenhua, laureate of the Sustainability Prize 2017, Dr. Mo Yan, a member of the Prize Recommendation Committee, Mr. Zhu Weiqun, Chairman of the Ethnic and Religious Affairs Committee of China, Mr. Geng Huichang, member of the Standing Committee of the Chinese People’s Political Consultative Conference and Vice-chairman of the Subcommittee of Hong Kong, Macao, Taiwan and Overseas Chinese, Mr. Zhigang Qin, Vice-chairman of the China Culture and Art Association, and a number of experts and scholars from political and academic circles gathered with more than 200 teachers and students of Peking University to participate in the symposium entitled “Facing the World: The Role, Opportunities and Challenges of Promoting Sustainable Development in China“. Dr. Lui Che Woo and Mrs. Lui also attended the unveiling ceremony of the Peking University Life Science Research Building, named the “Lui Che-woo Building” with Prof. Lin Jianhua and other guests, celebrating its completion and opening.  


Dr. Lui Che Woo, Founder of the “LUI Che Woo Prize – Prize for World Civilisation”, shared his experience of hardship in his early life during the opening speech and talked about his support for education.

(L-R)Prof. Tang Chao, Executive Dean of Academy for Advanced Interdisciplinary Studies and Chair Prof. of School of Physics of Peking University, Prof. Xu Zhihong, former President of Peking University, Dean of the College of Modern Agriculture Science, Prof. Rao Zihe, Selection Panel Member of the LUI Che Woo Prize and Prof. Zhang Dongxiao, Dean of the School of Graduate Studies and School of Engineering of Peking University, shared their views on sustainable development during the panel discussion.

Group photo: Dr. Lui Che Woo, leaders of Peking University and guest speakers.

Supporting the development of life sciences research and nurturing talents for the country

In 2017, Dr. Lui donated RMB 120 million to Peking University to set up the Lui Che Woo School of Life Sciences Fund and to construct a new Life Sciences building, continuing the pursuit of far-reaching and innovative research. Peking University’s new life science research building is named “Lui Che Woo Building” in gratitude to Dr. Lui for his dedication and significant contribution to the development of Peking University. Peking University also decided to appoint Dr. Lui as Honorary Trustee of Peking University, in order to gather the wisdom and experience of Dr. Lui, in further support of the development of the university.

Prof. Lin Jianhua said that he is thankful to Dr.Lui for his support of education and future generations and added that the establishment of the LUI Che Woo Prize reflects Dr. Lui’s broad-minded and profound thinking with regards to the challenges of human development. Prof. Lin Jianhua thanked Dr. Lui for his generous support of Peking University and was deeply delighted and inspired by his forward-looking and selfless dedication. Prof. Lin believes that advocating and establishing common values and visions are the foundations of society and university, which is also the intention of the LUI Che Woo Prize.  Prof. Lin expressed that Peking University is pleased to work with Dr. Lui Che Woo and all people with foresight to help the world understand China, and to let China understand the world with a broader mind and vision, moving towards world peace and a better future.

During the opening speech, Dr. Lui shared his experience of hardship early in his life and talked about his support for education. He believes that becoming a member of Peking University is an affirmation and great endorsement of his 89-year life. The support for the construction of “Lui Che Woo Building” is his appreciation to Peking University, to the country, to the compatriots, and to the world. He is looking forward to bringing great achievement to China in the area of life sciences, cultivating more outstanding talents and scientific research for the betterment of the country and the world. Dr. Lui said: “Let the revival of the five-thousand-year civilized country flourish with a humanistic glory. I know in my heart that this is where Peking University can make a unique contribution.” He believes that the future of Peking University will contribute more Chinese wisdom and spirit to the entire human society. As a “Chinese who has the privilege of doing something in the world,” Dr. Lui suggested: “Keep learning, making progress, embracing the world, facing the future, and creating achievements.”

Inspiring teachers and students to care about sustainable development

Mr. Xie delivered a speech at the symposium and stated that Dr. Lui has always practiced the vision of sustainable development, and he continues to take action, devote his energy, and strengthen his determination. The LUI Che Woo Prize shows that Chinese entrepreneurs take the social responsibility and promote sustainable development and he believes the Prize will lead more entrepreneurs to engage in sustainable development and contribute to a beautiful China.

Dr. Mo Yan said in his speech that Dr. Lui believes in good faith and good deeds. The establishment of the LUI Che Woo Prize aims to solve the impact of rapid development of materials and technology on morality, thereby improving the relationship between people, and between man and nature, so that individuals can pursue and achieve their goals, cherish and enjoy the beauty of the world, promote social harmony and common prosperity, and provide a better world for future generations. This is the Chinese peoples’ commitment to the world and its contribution to human society.

Prof. Xu Zhihong, former President of Peking University and Dean of the College of Modern Agriculture Science, Prof. Rao Zihe, Selection Panel Member of the LUI Che Woo Prize, Prof. Zhang Dongxiao, Dean of the School of Graduate Studies and School of Engineering of Peking University, and Prof. Tang Chao, Executive Dean of Academy for Advanced Interdisciplinary Studies and Chair Prof. of School of Physics of Peking University, shared their views on the importance of sustainable development during the panel discussion at the symposium, and answered questions from teachers and students. Prof. Xu Zhihong believes that universities should cultivate and encourage students to think about sustainable development. He suggested that every Chinese citizen, especially well-educated citizens, should have such a mindset, starting from oneself, and that this is the only hope for the future of China. Prof. Rao Zihe said that the LUI Che Woo Prize focuses on the overall contribution to mankind through its high assessment requirements and standards. He also said that the Prize will have a greater influence in the international community in the future. Prof. Zhang Dongxiao then spoke about the close relationship between development and sustainability, the prospects for future cooperation in energy development between China and the United States, and the direction of China’s energy structure adjustment.

After the symposium was completed, the guests gathered at “Lui Che Woo Building”, where Prof. Wu Hong, Dean of the School of Life Sciences of Peking University, introduced the “Lui Che Woo Building”. She said that the building will provide an innovative space for Peking University Life Science scholars, where the university will cultivate promising young people to contribute to China and the world, and that it will also serve as a bridge between Peking University and the world’s life sciences. Under the witness of teachers and students, Dr. Lui Che Woo and Mrs. Lui, Mr. Lawrence Lui Yiu Nam, the son of Dr. Lui, representative of LUI Che Woo Charity of the United States, Prof. Lin Jianhua, Prof. Xu Zhihong and Prof. Wu Hong lit a crystal ball and unveiled the “Lui Che Woo Building”, as well as a commemorative plaque for the building.

About the LUI Che Woo Prize – Prize for World Civilisation

Founded by Dr. LUI Che Woo in 2015, the “LUI Che Woo Prize – Prize for World Civilisation” is an annual, first of its kind international cross-sector innovative award for advancing world civilisation and inspiring people to build a more harmonious world. It aims to recognise and honour individuals or organisations all over the world for outstanding contributions and encourages the continuation of that work in three objectives: sustainable development of the world, betterment of the welfare of mankind and promotion of positive life attitude and enhancement of positive energy. For more details, please go to www.luiprize.org.

About Dr. LUI Che Woo

Dr. Lui Che-woo was born in Jiangmen, Guangdong Province, China in 1929. He established the first K. Wah company in Hong Kong in the 1950s. He is currently Chairman of K. Wah Group. Its major member companies include K. Wah International Holdings Limited, Galaxy Entertainment Group Limited, Stanford Hotels International and K. Wah Construction Materials Limited. Today, K. Wah Group has developed into a multi-national conglomerate, one of Asia’s largest and leading conglomerates involving diversified businesses including properties, entertainment and leisure, hospitality, and construction materials with over 200 subsidiaries and close to 30,000 employees worldwide. The foothold of the business covers Hong Kong, Mainland China, Macau, North America and Southeast Asia. A distinguished philanthropist, Dr. Lui has been particularly supportive of the development of medical care, education and hotel and tourism industries. In 2014, Dr. Lui established a HK$1.3 billion GEG Charitable Foundation to cultivate in the young proper moral values and nurture their sense of belonging to society and the community.

About LUI Che Woo Prize Limited (“Prize Company”)

The Prize Company is a charitable company limited by guarantee incorporated in Hong Kong. Nomination and its related work are handled by the Secretariat. The Prize Company is led and supervised by the Board of Governors and is responsible for the daily administration, coordination and liaison with the Board of Governors, the Prize Council, the Prize Recommendation Committee and the Selection Panels to ensure the highest standards of integrity and transparency in relation to the Prize are upheld.

Photo – https://photos.prnasia.com/prnh/20180629/2177060-1-a
Photo – https://photos.prnasia.com/prnh/20180629/2177060-1-b
Photo – https://photos.prnasia.com/prnh/20180629/2177060-1-c

Editor’s Note: Never Too Late

Hands up please to those of you who began the year with the resolution to lose weight. Be honest. I am one of those people.

It all began with sitting by the beach, waiting for the fireworks display, that we started talking about our New Year resolutions. Although it’s mostly about body goals, losing weight is an important factor as 75% of us who were there were overweight.

For me, I began my body transformation completely mad – threw myself into exercising and crash dieting. That ended up pretty bad. I had injuries and binge-ate most times.

Took me a while to get into the groove of things while my friends are already seeing results. That did not hamper my enthusiasm to achieve my goals though. In fact, it encouraged me further.

I decided to adopt a healthier lifestyle and more realistic goals. The goal in the adoption was to change habits and mindset.

It may be July now but I feel as if it’s January and I’m just starting to finally realign myself towards a better me. There is no excuse to stop achieving goals set out on that beach on New Year’s just because it’s the middle of the year. The best time to begin working on a better you is now.

 

My weight as of 1 January 2018: 71kg

My current weight: 67kg

I-Mab Successfully Raised USD 220 Million in Series C Funding

SHANGHAI, June 29, 2018 /PRNewswire/ — I-Mab Biopharma, a company focusing on innovative Biologics in therapeutic areas of immuno-oncology and immuno-inflammation, announced the completion of Series C financing for USD 220 million, representing one of the largest amounts ever raised in Series C by an innovative biotech company in China. This round of funding was led by Hony Capital, with participations from Hillhouse Capital, HOPU Investments, CDH Investment, Ally Bridge Group, Singapore-based EDBI, and existing investors C-Bridge Capital and Tasly Capital. China Renaissance was designated as the sole financial advisor for this series of financing.


I-Mab Management Team

The proceeds of the financing will be used primarily to advance the pre-clinical and clinical development of a number of Best-in-Class and First-in-Class assets.

As a China-based innovative company specialized in oncology and autoimmune diseases, I-Mab Biopharma has rapidly built a globally competitive pipeline through its unique strength in target biology, antibody engineering as well as pre-clinical & clinical development. Currently, I-Mab has more than ten investigational drugs under development, and has forged partnerships with leading biotech and pharma companies, such as Genexine, Ferring Pharmaceuticals, MorphoSys AG, and CROs, which include WuXi Biologics, TigerMed and others.

A fresh round of fundraising came at the heels of the Company’s Series B financing of USD 150 million in March, 2017, and by retaining the world’s top investors in this round, I-Mab further demonstrated its development strengths and capabilities in innovative antibodies globally. 

“We are very proud that our innovative research and clinical development capabilities are recognized by the leading investors. In a very short time, I-Mab has built a globally competitive pipeline and a highly experienced team to deliver the pipeline milestones. This round of financing will facilitate further development of our innovative assets in China and internationally”, said Dr. Jingwu Zang, the founder and CEO of I-Mab.

“We are very excited about participating in this round of financing. Hony Capital has a long-term relationship with Dr. Zang and highly values his management team. I-Mab is uniquely positioned with a sharp focus on the development of innovative medicines. It has established a globally competitive pipeline through a compelling strategy and an elite team with strong R&D capabilities. Hony Capital is highly confident about I-Mab’s ability to leverage on its resources and attain future success,” said Bing Yuan, Managing Director of Hony Capital.

“I-Mab has made remarkable progress in delivering company and project milestones as well as assembling a world class team, C-Bridge Capital is honored to make a further investment in I-Mab, and we believe that I-Mab will be able to fulfill its mission to develop transformational medicines to improve the lives of patients around the world,” commented Wei Fu, Founding Partner of C-Bridge Capital.

About I-Mab:

Facilitated by a merger between Third Venture Biotech and Tasgen Bio, which was followed by a Series B financing of USD 150 million in 2017, I-Mab has rapidly built a world-class R&D capability and highly experienced team.

I-Mab focuses on discovery and development of First-in-Class and Best-in-Class biologics in the areas of immuno-oncology and immuno-inflammation. The company has already submitted several IND applications and is prepared to submit additional INDs in order to initiate clinical trials in China and the US, including multiple Phase 2 and Phase 3 studies. I-Mab is on a fast track toward becoming an end-to-end fully integrated biopharma company. 

Photo – https://photos.prnasia.com/prnh/20180629/2176887-1

The 4th China-Israel Investment Summit will begin on July 2nd

ZHUHAI, China, July 1, 2018 /PRNewswire/ — The 4th China-Israel Investment Summit will be held at the Zhuhai International Convention and Exhibition Center from July 2nd to 3rd. This summit is guided by National Development and Reform Commission of China, Ministry of Regional Cooperation of Israel, Ministry for Social Equality of Israel, and the People’s Government of Guangdong Province, hosted by International Cooperation Center of National Development and Reform Commission of China, the Consulate General of Israel in Guangzhou, and the People’s Government of Zhuhai Municipality, co-organized with Ministry of Economy and Industry of Israel, Development and Reform Commission of Guangdong Province, Economic and Information Commission of Guangdong Province, Department of Science and Technology of Guangdong Province, Department of Commerce of Guangdong Province, People’s Government of Shantou Municipality, Zhuhai Huafa Group and Infinity Group of Israel.


The 4th China-Israel Investment Summit will begin on July 2nd

The conference will focus on the theme of “Innovation Cooperation for a Bright and Smart Future in the Guangdong – Hong Kong-Macao Greater Bay Area” and combined with Zhuhai’s development direction for emerging industries, formulate a conference main forum and five industry sub-forums involving new and emerging industries of science and technology, namely Smart Manufacturing 2025, Digital Economy, Biomedicine, Intellectual Property, and Smart City. At the same time, it will conduct precise peer-to-peer invitations and dockings, hold Sino-Israeli B2B “one-on-one” docking exchanges, promote the economic and trade cooperation as well as the introduction of investment projects between China and Israel, and propel the healthy and rapid development of emerging industries in Zhuhai.

The summit invited officials like Mr. Nagev Cohen, who is the Consulate General of Israel in Guangzhou, and Mr. Tzachi Hanegbi, who is the Isreali Minister of Regional Cooperation. This deepens the exchange and cooperation between China and Israel. Other senior representatives, including Mr. Yao Yudong, former Director of the Financial Research Institute of People’s Bank of China, Mr. Yu Yi, President and Managing Director of Greater China of Accenture Digital Services, Mr. Xiong Yi, IBM Global Vice President, Ms. Dong Mingzhu, Chairperson and President of Zhuhai Gree Electric Appliance Co., Ltd, Mr. Wu Guangquan, Rresident and Departmental Secretary of Party Committee of China National Aero-Technology International Holdings Limited (AVIC International), Mr. Shraga Brosh, President of the Manufacturers’ Association of Israel, and Dr. Oded Shoseyov, Prof. Protein Engineering and Nano-Biotechnology of the Hebrew University of Jerusalem, will also attend the opening ceremony and join the discussion of topics such as Sino-Isreali technology & innovation cooperation and the development of the Guangdong – Hong Kong-Macau Greater Bay Area.

During the conference, Chinese and Israeli companies and institutions will hold negotiations and agreement-signings on dozens of cooperation projects, and there will be more than 2,000 B2B companies docking together. Tencent, Alibaba, IBM, IDG Capital, Accenture, ACAC, Foxconn, Beijing Automotive, and other publicly-known companies are among the participating companies, as well as elites in niche, such Hikvision, which ranks the first in video surveillance worldwide, Foxconn M Sub-group (Health Care Business Group) and others. The areas of cooperation include financial science and technology, industrial manufacturing, mobile communications and Internet, agricultural science and technology, and clean energy. The total investment involved is nearly 10 billion yuan.

As of June 27, 2,000 companies and organizations from China and Israel have registered for this summit with more than 5,000 participants, including nearly 250 representatives of Israeli government agencies and outstanding companies. Registered companies mainly cover industrial manufacturing and automation, mobile communications and Internet, clean energy, agricultural science and food technology, Internet of things, automotive technology, financial technology, industrial applications, life sciences, academic research and other fields.

Photo – https://photos.prnasia.com/prnh/20180701/2177794-1

Mobike’s Amazing Bike-Sharing Stats in China

Mobike, the bike-sharing company that began its operation in China, released some pretty awesome stats on its 2017 usage in the country. Last year saw 9 million bikes being shared by users in Beijing alone.

The stats released by them are not concentrated in Beijing alone though and they have teamed up with the China New Urbanization Research Institute to analyze just how their bikes are utilized.

Here are some of their stats.

2.5 billion kilometers traveled

Image from Mobike’s White Paper

Using bicycles to connect to public transport

Image from Mobike’s Bike-Sharing Whtie Paper

Saving urban space

Image from Mobike’s Bike-Sharing Whtie Paper

More male than female users

Image from Mobike’s Bike-Sharing Whtie Paper

What Mobikes are used for

Image from Mobike’s Bike-Sharing Whtie Paper

This article was originally posted at Time Out Beijing. Click here to view Mobike’s White Paper.

10 times faster MR liver scan – United Imaging introduced new technologies at ISMRM 2018

  • Single-scan multi-contrast technology — allowing accurate examination of multiple sclerosis and other brain diseases, developed through close collaborations among United Imaging, Sungkyunkwan University (SKKU) and the PLA General Hospital (PGH).
  • Constellation shuttling imaging technology — allowing new breakthroughs in fast MR imaging.
  • New radial cardiac cine technology — significantly improving cardiac cine MR.

SHANGHAI, June 26, 2018 /PRNewswire/ — The 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2018) was recently held in Paris, France. Shanghai United Imaging Healthcare Co., Ltd. (United Imaging), as the only Chinese corporate member of ISMRM, attended this event for the 7th consecutive year and unveiled a suite of new technologies.

Dr. Qiang “Al” Zhang, Co-President of United Imaging, offered his insight into the future MR: “We believe that the future MR will be faster, easier to use, and provide richer clinical and scientific information. Therefore, United Imaging has been focusing on developing new technologies on fast MR imaging. We are also complementing MR with healthcare IT and medical artificial intelligence to provide more valuable solutions to clinical diagnosis.”

Faster: Single-scan multi-contrast technology allowing accurate examination of multiple sclerosis and other brain diseases.

During the conference, a member from the Professor Jaeseok Park team of SKKU gave a presentation on multi-contrast MRI single-scan technology. Thanks to the close collaborations among United Imaging, SKKU, and the PGH, this fast MR scan technology combines constellation shuttling (CS) with multi-contrast single-scan and data sharing technologies for the first time. This technology can achieve an acceleration factor of up to 10, enabling high-resolution and isotropic 3D scanning of a whole brain with 4 image contrasts – T1, T2, FLAIR, and DIR, in only 5 minutes.

As reported by the SKKU presenter: “Scanning speed and image resolution are two conflictive parts in MR scans. With United Imaging, we have jointly developed a multi-contrast imaging technology that uses data sharing technology to accomplish high-speed, high-resolution 3D imaging. Based on this feature, the technology has made major breakthroughs in precise disease diagnosis and human brain cognition and provides a standardized operational basis for medical big data and artificial intelligence. Going forward, we will be exploring more unknown areas based on this powerful scientific research platform. “

Professor Xin Lou from the PGH explained that the multi-contrast single-scan technology is of great significance to the diagnosis of diseases such as multiple sclerosis (MS). MS is a chronic disease that attacks the patient’s spinal cord, brain, and optic nerves. It is difficult to differentiate the stationary lesion of MS from the recurrent lesion with conventional 2D scan.

“This technology makes high-resolution 3D cranial imaging a reality. It is able to capture micro lesions in any location, ensuring precise diagnosis and evaluation. It also supports the non-invasive imaging of physiological changes, facilitates the qualitative diagnosis of the disease, monitors the progress of the disease, and evaluates the efficacy of treatment,” said Professor Lou.

Constellation Shuttling imaging technology (CS): new breakthroughs in fast MR imaging

During last year’s ISMRM, United Imaging announced its Constellation Shuttling (uCS) technology. Over the past year, United Imaging has applied uCS to a wide range of clinical and research applications with in-depth collaborations with a number of top hospitals and research institutes in China. A couple of applications are listed below:

  • Abdomen applications

With an acceleration factor up to 16, multi-phase dynamic abdominal MR scans can be acquired without breath-hold, and continuous changes in the tissue signals can be accurately recorded with this “dynamic 3D whole-liver imaging”, according to the uCS clinical results reported by the Fudan University-affiliated Zhongshan Hospital in Shanghai, China.

  • Bone and joint applications

The MSK application of uCS platform brings a 5-6 times faster scan and 0.5mm3 isotropic imaging, offering doctors refined images with high resolution and finer voxels for accurate diagnosis. Courtesy of Peking University Third Hospital.

Easier to use: Radial cardiac cine technology significantly improving cardiac cine MR.

Dr. Qi Liu, a United Imaging senior MRI scientist, presented a breakthrough in MRI technology at the conference. Cardiac MR imaging is challenged by patient discomfort, motion artifact and poor image quality.

Using its innovative Golden-angle Radial acquisition and Angle-Based echo-Sharing technique (GRABS), United Imaging has achieved significant reduction in image artifacts, enabling more than threefold improvements in signal-to-noise ratio. Clinical trials of GRABS are already being carried out on a 3.0T United Imaging MRI at Wuhan University-affiliated Zhongnan Hospital in Wuhan, China. Professor Haibo Xu, Chair of the hospital’s Radiology Department, explained, “With this new technique, our cardiac MR imaging is much less sensitive to motion and thus produces a greatly improved image quality. It helps our doctors accurately measure those cardiac function parameters.”

 During the ISMRM, United Imaging also hosted a “United Imaging Night” to discuss the future of MR and share the progress of United Imaging with more than 200 MR experts, scholars, and students from across the world.

Dr. Min Xue, Chairman of the Board and Chief Executive Officer of United Imaging, stated, “As people are paying more attention to their health, MR imaging is facing unprecedented growth opportunities. For the past seven years, United Imaging has successfully developed and launched a series of products and technologies, and has made quality medical care accessible to more patients with innovative medical IT and AI applications. Currently, United Imaging is poised for global markets. We hope that more top talents will join us, help to maximize the values of MR, and together, bring equal healthcare for all!”

About UIH

Shanghai United Imaging Healthcare Co., Ltd. (UIH) develops and produces a full portfolio of advanced medical products covering the entire process of imaging diagnosis and treatment, and offers innovative medical IT solutions. Founded in 2011 and headquartered in Shanghai, United Imaging has established R&D centers worldwide.

http://www.united-imaging.com/en/home/

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Source: Shanghai United Imaging Healthcare Co., Ltd.

PwC Hong Kong signs investment agreement with biotech and internet platform company Vitargent

-Stronger alliance will forge better future for food safety

HONG KONG, June 29, 2018 /PRNewswire/ — PwC Hong Kong (“PwC”) has entered into an investment agreement today with Vitargent International Holdings Limited (“Vitargent”), a pioneer in bio-testing technology for product safety. This is PwC’s first proposed investment in the biotechnology and internet platform space, bringing together the strengths of PwC and Vitargent to address evolving challenges in food and consumer product safety across Greater China and beyond.


PwC has entered into an investment agreement today with biotech and internet platform company Vitargent.

Raymund Chao, PwC Asia Pacific and Greater China Chairman, and Jimmy Tao, Chief Executive Officer, Vitargent, officiated at a signing ceremony held in Hong Kong today.

Vitargent is an award-winning biotechnology company specialising in product safety testing with its pioneering fish-embryo based toxicity testing technology. Backed by 10+ institutional investors and with input from its Scientific Advisory Board comprising experts from across the globe, Vitargent’s technology is serving 50+ leading companies and organisations including governments, research institutes, testing laboratories, major international skincare and cosmetics companies, food manufacturers and catering groups around the world.

Since forming a strategic alliance earlier this year in February, PwC and Vitargent have worked collaboratively to build a professional team of over 30 experts, actively providing a holistic one-stop solution to food manufacturers and suppliers to improve their quality of products and giving accreditation to companies that offer excellent quality. Vitargent also issues Test-it™ reports and safe-to-buy product lists to the public with PwC as a strategic partner providing professional services and a foundation for public trust across our markets. Our combined expertise brings these product safety resources to market equipping the public with better knowledge to make safer choices, and serving as an important tool for consumers to gain trust in brands and manufacturers.

Raymund Chao says, “We are delighted to establish a deeper relationship with Vitargent, whose innovative testing solutions complement PwC’s professional capabilities to tackle longstanding challenges in food integrity. This investment agreement is a significant step in furthering PwC’s purpose of solving important problems and building trust in society. By staying at the forefront of food safety innovations, PwC aims to reinforce our end-to-end services to help clients strengthen their competitive advantage, enhance consumer confidence and protect and enhance their reputation. Looking ahead, we are ready to deliver greater value to the food and consumer markets, with a focus on driving commercial growth while balancing that with consumer trust and regulatory concerns. Together, we can work towards building a safer and more sustainable future in food and other consumer products.”

Jimmy Tao says, “We are pleased to have PwC’s support in solving food safety issues and enhancing public trust in food supply. Food safety measures must be prioritised, in view of the global food safety violations and recalls of food in supply over the last decade. We will work closely to ensure food manufacturers and suppliers, across Greater China and beyond, will benefit from Vitargent’s advanced bio-toxicity testing technology, which provides early warnings to unsafe products and helps avoid potentially disastrous consequences. By sharing our industrial experience and expertise, we are setting a safety standard that is beyond regulatory requirements. We are building the world’s largest database of bio-data for consumer products that will add value to business and instil confidence to consumers and other stakeholders.”

Notes to Editors

About Vitargent

With nearly 15 years of biotechnology research and development and achievement by the co-founders, Vitargent commercialised the technology in 2010 with the vision of “Smarter Testing, Safer Products, Better World”. We are a pioneer in the field of applying fish embryo-based toxicity testing technology to ensure product safety. We are the proud winners of the Grand Prix at the International Exhibition of Inventions of Geneva (2015). We are backed by 10+ institutional investors. With hands-on guidance from our world-renowned Scientific and Business Advisory Boards, we combine technological expertise with social responsibility. We aid manufacturers to improve product safety and enhance consumers’ confidence in making safer purchases. We have served over 50+ top-notch testing organisations, governments, research institutes, major international skincare and cosmetics companies and catering groups around the world. With the firm support of these entities, we are working towards incorporating the technology into regional and international safety standards.

About Test-it™

Test-it™ is the consumer information product safety platform under Vitargent, the world’s first with Testing 2.0 bio-testing technology. It provides information for consumers to access in everyday lives. Find out more by visiting us at www.fishqc.com.

About PwC

At PwC, our purpose is to build trust in society and solve important problems. We are a network of firms in 158 countries with more than 236,000 people who are committed to delivering quality in assurance, advisory and tax services. In China, including Hong Kong, we have over 18,000 people and are located in 23 cities.

Consumer confidence around food safety is a very significant societal concern, China’s food sector is evolving rapidly. PwC’s Food Supply & Integrity Services combine food industry expertise with our capabilities in risk management, internal controls, supply chain, strategy, compliance, capital markets and M&A to help our clients achieve lasting success. Our services enable a variety of clients to deliver safe, quality food while building growing and profitable businesses. 

Media Contact:

Wing Kwong, Vitargent
Email:
wing.kwong@vitargent.com

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EDGC Celebrates Listing on KOSDAQ

Successfully Listed on KOSDAQ

SEOUL, South Korea, June 29, 2018 /PRNewswire/ — Eone-Diagnomics Genome Center (EDGC; Co-CEO, Minseob Lee, Shangcheol Shin), the global leading company in genomic analysis, has successfully completed the ceremony celebrating its listing on the Korea Securities Dealer Automated Quotation (KOSDAQ) at the Korea Exchange on June 26.


EDGC has successfully completed the ceremony celebrating its listing on KOSDAQ at the Korea Exchange on June 26.

EDGC is the international joint venture between Eone Life Science Institute in South Korea and Diagnomics in the Unites States of America. EDGC was established in 2013. It analyzes personal genes based on big-data technology, predicts genetic diseases and suggests personalized lifestyles to prevent diseases.

EDGC mainly provides clinical and consumer genetic services based on Next Generation Sequencing (NGS) technology: the first integrated genotype and phenotype test ‘MYGENPLAN™’, personalized medical check-up ‘gene2me®Plus’, inherited ophthalmologic genetic screening test ‘MyEyeGene®‘, non-invasive prenatal test ‘NICE®‘, newborn genetic screening test ‘bebegene®‘ and so on. In addition, it has focused to enhance its competitiveness through the business expansion into the area of liquid biopsy, transplant rejection.

EDGC is striving to develop and dominate overseas markets including the Chinese market. It plans to accelerate and make headway in the market by providing genomic analysis services and transferring technologies to overseas companies. Current services available in Southeast Asia and Middle East have provided excellent business results. To target overseas markets, it has acquired domestic and international certifications including, College of American Pathologists (CAP), Clinical Laboratory Improvement Amendments (CLIA), CommunauteEuropeen (CE), International Organization for Standardization (ISO) 13485.

The business value of EDGC is estimated at KRW 400 billion. The largest shareholders of EDGC are Cheol Ok Lee, Chairman of Eone Life Science Institute, largest commercial laboratory in South Korea; Kolmar Korea Holdings which is the global No. 1 in cosmetics Original Design Manufacturing (ODM); and Jun Il Kim, Founder of Lock & Lock. EDGC has attracted attention from the public prior to its listing due to the strong business results.

Shang Cheol Shin, co-CEO of EDGC, said listing on the KOSDAQ is the result of efforts by numerous people, and he added EDGC will help all the people improve their health and welfare and finally become the company which proposes the change of paradigm.

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China Jo-Jo Drugstores Reports Fiscal Year 2018 Financial Results

HANGZHOU, China, June 30, 2018 /PRNewswire/ — China Jo-Jo Drugstores, Inc. (NASDAQ: CJJD) (“Jo-Jo Drugstores” or the “Company”), a leading online and offline retailer and wholesale distributor of pharmaceutical and other healthcare products and a healthcare provider in China, today announced its financial results for the fiscal year ended March 31, 2018.

Mr. Lei Liu, Chief Executive Officer and Chairman of Jo-Jo Drugstores, Inc., commented, “Fiscal year 2018 has been an important transition year for China Jo-Jo Drugstores with revenues increased by 17.9% year-over-year to $96.11 million. We expanded our retail business, opening 55 new retail drugstores in key locations, and continued to improve services in our existing stores. While our e-commerce business continued its transition following the suspension of OTC drug sales on e-commerce platforms in fiscal year 2017, in the third and fourth quarters of fiscal 2018, our online pharmacy results began to stabilize as we optimized our product range.”

Mr. Liu continued, “We expect our efforts to focus on product selection and price negotiation with suppliers to increase our sales profit margin. Our e-commerce segment will continue its evolution following our initiatives to cooperate with commercial insurance companies, such as the People’s Insurance Company of China, and other active strategies. We look forward to executing our business objectives and we believe that there is still plenty of room for us to continue to grow at a rapid rate in the foreseeable future.”

Fiscal Year 2018 Financial Highlights

For the Fiscal Year Ended March 31,

($ millions, except per share data)

2018

2017

 Change

Revenues

96.11

81.50

17.9%

      Retail drugstores

61.98

51.79

19.7%

      Online pharmacy

12.13

15.39

(21.2%)

      Wholesale

22.00

14.32

53.6%

Gross profit

20.13

16.63

21.0%

Gross margin

20.9%

20.4%

0.5 pp*

Loss from operations

(18.02)

(6.10)

195.5%

Net loss attributable to Jo-Jo Drugstores

(17.06)

(5.64)

202.3%

Loss per share

(0.68)

(0.28)

141.4%

*Notes: pp represents percentage points

  • Revenues increased by 17.9% to $96.11 million for the fiscal year ended March 31, 2018 from $81.50 million for the last fiscal year, mainly due to the increase in retail drugstores and wholesale business, partially offset by the decrease in online pharmacy business.
  • Gross profit increased by 21.0% to $20.13 million for the fiscal year ended March 31, 2018 from $16.63 million for the last fiscal year. Gross margin increased by 0.5 percentage points to 20.9% from 20.4% for the last fiscal year.

Fiscal Year ended March 31, 2018 Financial Results

Revenue

Revenue for the fiscal year ended March 31, 2018 increased by $14.61 million, or 17.9%, to $96.11 million from $81.50 million for the last fiscal year. The increase in revenue was primarily due to the increase in retail drugstores and wholesale business, partially offset by the decrease in online pharmacy business.

For the Fiscal Year Ended March 31,

2018

2017

($ millions)

Revenues

Cost of
Goods

Gross
Margin

Revenues

Cost of
Goods

Gross
Margin

Retail drugstores

61.98

45.92

25.9%

51.79

38.09

26.5%

Online pharmacy

12.13

10.86

10.5%

15.39

13.83

10.1%

Wholesale

22.00

19.21

12.7%

14.32

12.95

9.6%

Total

96.11

75.99

20.9%

81.50

64.87

20.4%

Revenue from the retail drugstores segment increased by $10.19 million, or 19.7%, to $61.98 million for the fiscal year ended March 31, 2018 from $51.79 million for the last fiscal year. The increase was primarily due to the increased number of stores, close monitoring of health products suitable to communities, brand-name health product sales campaign in cooperation with brand name suppliers, and value-added customer services such as chronic disease monitoring.

Revenue from the online pharmacy segment decreased by $3.26 million, or 21.2%, to $12.13 million for the fiscal year ended March 31, 2018 from $15.39 million for the last fiscal year. The decrease was mainly caused by a decline in our sales via e-commerce platforms. The decline in sales was due to the suspension of OTC drug sales on e-commerce platforms in the second quarter of fiscal year 2017 by the CFDA. The Company is adding more non-medical health products such as nutritional supplements into our sales menu to counteract the decline in sales of OTC drug category via e-commerce platforms.

Revenue from the wholesale segment increased by $7.68 million, or 53.6%, to $22.00 million for the fiscal year ended March 31, 2018 from $14.32 million for the last fiscal year. The increase was primarily a result of the Company’s ability to resell certain products, which our retail stores made large orders on, to other vendors at competitive prices.

Gross profit and gross margin

Total cost of goods sold increased by $11.12 million, or 17.1%, to $75.99 million for the fiscal year ended March 31, 2018 from $64.87 million for the last fiscal year. Gross profit increased by $3.50 million, or 21.0%, to $20.13 million for the fiscal year ended March 31, 2018 from $16.63 million for the last fiscal year. Overall gross margin increased by 0.5 percentage points to 20.9% for the fiscal year ended March 31, 2018, compared to 20.4% for the last fiscal year.

Gross margins for retail drugstores, online pharmacy and wholesale were 25.9%, 10.5%, and 12.7%, respectively, for the fiscal year ended March 31, 2018. This compared to gross margins for retail drugstores, online pharmacy and wholesale of 26.5%, 10.1%, and 9.6%, respectively, for the last fiscal year.

Loss from operations

Sales and marketing expenses increased by $5.82 million, or 45.0%, to $18.74 million for the fiscal year ended March 31, 2018 from $12.92 million for the last fiscal year, primarily due to increase in labor and rent related to our store expansions and rising local living cost.

General and administrative expenses increased by $10.14 million, or 131.9%, to $17.82 million for the fiscal year ended March 31, 2018 from $7.68 million for the last fiscal year. The increase in general and administrative expenses was primarily due to the increased number of administrative staff and their compensation, as well as additional accounts receivable and advances to vendors allowance of $4.7 million in the fiscal year ended March 31, 2018 as compared to an increase of $0.7 million in allowance in the year ended March 31, 2017.

Impairment of long-lived assets was $1.58 million for the fiscal year ended March 31, 2018, compared to $2.12 million for the last fiscal year. Jiuxin Medicine started outsourcing its logistics service to Astro Boy Cloud Pan (Hangzhou) Storage and Logistics Co. Ltd, Jiuxin Medicine’s warehouse lease has been terminated. As a result, approximately unamortized $1,583,186 warehouse improvement is recognized as expense in the year ended March 31, 2018. Such impairment was made after we estimated that the implied fair value of long-lived assets was lower than the carrying value.

Loss from operations increased by $11.92 million, or 195.5%, to $18.02 million for the fiscal year ended March 31, 2018 from $6.10 million for the last fiscal year. Operating margin was negative 18.8% for the fiscal year ended March 31, 2018, compared to negative 7.5% for the last fiscal year.

Net loss

Net loss attributable to common shareholders for the fiscal year ended March 31, 2018 was $17.06 million, or $0.68 per basic and diluted share. This compared to net loss attributable to common shareholders of $5.64 million, $0.28 per basic and diluted share, for the last fiscal year.

Financial Condition

As of March 31, 2018, the Company had cash of $15.13 million, compared to $18.36 million as of March 31, 2017. Net cash used in operating activities was $2.07 million for the fiscal year ended March 31, 2018, compared to net cash provided by operating cash flow of $1.56 million for the last fiscal year. Net cash used in investing activities was $2.98 million for the fiscal year ended March 31, 2018, compared to $0.05 million for the last fiscal year. Net cash used in financing activities was $0.77 million for the fiscal year ended March 31, 2018, compared to net cash provided by financing activities of $10.64 million for the last fiscal year.

About China Jo-Jo Drugstores, Inc.

China Jo-Jo Drugstores, Inc. (“Jo-Jo Drugstores” or the “Company”), is a leading online and offline retailer and wholesale distributor of pharmaceutical and other healthcare products in China. Jo-Jo Drugstores currently operates retail drugstores and an online pharmacy. It is also a wholesale distributor of products similar to those carried in its pharmacies and it cultivates and sells herbs used for traditional Chinese medicine. For more information about the Company, please visit http://www.chinajojodrugstores.com/. The Company routinely posts important information on its website.

Forward-Looking Statements

This press release contains information about the Company’s view of its future expectations, plans and prospects that constitute forward-looking statements. Actual results may differ materially from historical results or those indicated by these forward-looking statements as a result of a variety of factors including, but not limited to, risks and uncertainties associated with its ability to raise additional funding, its ability to maintain and grow its business, variability of operating results, its ability to maintain and enhance its brand, its development and introduction of new products and services, the successful integration of acquired companies, technologies and assets into its portfolio of products and services, marketing and other business development initiatives, competition in the industry, general government regulation, economic conditions, dependence on key personnel, the ability to attract, hire and retain personnel who possess the technical skills and experience necessary to meet the requirements of its clients, and its ability to protect its intellectual property. The Company’s encourages you to review other factors that may affect its future results in the Company’s annual reports and in its other filings with the Securities and Exchange Commission.

For more information, please contact:

Company Contact: 

Frank Zhao
Chief Financial Officer
+86-571-88077108
frank.zhao@jojodrugstores.com

Steve Liu
Investor Relations Director
steve.liu@jojodrugstores.com

Investor Relations Contact:

Tina Xiao
Ascent Investor Relations LLC
+1-917-609-0333
tina.xiao@ascent-ir.com

CHINA JO-JO DRUGSTORES, INC. AND SUBSIDIARIES

CONSOLIDATED BALANCE SHEETS

March 31,

March 31,

2018

2017

ASSETS

CURRENT ASSETS

Cash

$

15,132,640

$

18,364,424

Restricted cash

16,319,551

9,431,386

Financial assets available for sale

175,140

87,068

Notes receivable

279,082

253,394

Trade accounts receivable, net of allowance for doubtful accounts of $4,561,314 and
    $1,415,505, as of March 31, 2018 and 2017 respectively

8,322,393

8,561,596

Inventories

13,429,568

9,923,101

Other receivables, net of allowance for doubtful accounts of $ 184,720 and $26,854,
    as of March 31, 2018 and 2017, respectively

3,098,079

2,269,193

Advances to suppliers, net of allowance for doubtful accounts of $3,058,092 and
    $1,502,255, as of March 31, 2018 and 2017, respectively

3,447,452

5,504,141

Other current assets

2,116,237

1,566,155

Total current assets

62,320,142

55,960,458

PROPERTY AND EQUIPMENT, net

2,843,640

4,263,157

OTHER ASSETS

Long-term investment

40,890

46,152

Farmland assets

796,286

718,787

Long term deposits

2,501,968

2,294,848

Other noncurrent assets

1,253,352

1,177,005

Intangible assets, net

4,056,414

2,712,611

Total other assets

8,648,910

6,949,403

Total assets

$

73,812,692

$

67,173,018

LIABILITIES AND STOCK HOLDERS’ EQUITY

CURRENT LIABILITIES

Short-term loan payable

$

$

Accounts payable, trade

25,259,526

19,441,195

Notes payable

19,180,200

12,691,575

Other payables

4,272,523

2,916,283

Other payables – related parties

850,342

927,052

Customer deposits

4,040,867

2,675,030

Taxes payable

366,040

681,939

Accrued liabilities

841,993

679,350

Total current liabilities

54,811,491

40,012,424

Purchase option and warrants liability

138,796

496,217

Total liabilities

54,950,287

40,508,641

COMMITMENTS AND CONTINGENCIES

STOCKHOLDERS’ EQUITY

Common stock; $0.001 par value; 250,000,000 shares authorized; 28,936,778 and
    25,214,678 shares issued and outstanding as of March 31, 2018 and March 31,
    2017

28,937

25,215

Preferred stock; $0.001 par value; 10,000,000 shares authorized; nil issued and 
    outstanding as of March 31, 2018 and March 31,2017

Additional paid-in capital

43,599,089

36,581,248

Statutory reserves

1,309,109

1,309,109

Accumulated deficit

(29,661,190)

(12,601,257)

Accumulated other comprehensive income

3,586,460

1,350,062

Total stockholders’ equity

18,862,405

26,664,377

Total liabilities and stockholders’ equity

$

73,812,692

$

67,173,018

CHINA JO-JO DRUGSTORES, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS

For the years ended
March 31,

2018

2017

REVENUES, NET

$

96,112,706

$

81,499,045

COST OF GOODS SOLD

75,987,537

64,872,127

GROSS PROFIT

20,125,169

16,626,918

SELLING EXPENSES

18,739,492

12,923,192

GENERAL AND ADMINISTRATIVE EXPENSES

17,823,661

7,684,862

IMPAIRMENT OF LONG-LIVED ASSETS

1,583,186

2,117,042

TOTAL OPERATING EXPENSES

38,146,339

22,725,096

LOSS FROM OPERATIONS

(18,021,170)

(6,098,178)

INTEREST INCOME

478,976

379,790

INTEREST EXPENSE

(1,349)

OTHER INCOME, NET

201,096

19,888

CHANGE IN FAIR VALUE OF PURCHASE OPTION AND WARRANTS
LIABILITY

357,421

140,032

LOSS BEFORE INCOME TAXES

(16,983,677)

(5,559,817)

PROVISION FOR INCOME TAXES

76,256

84,387

NET LOSS

(17,059,933)

(5,644,204)

OTHER COMPREHENSIVE LOSS

Foreign currency translation adjustments

2,236,398

(1,507,751)

COMPREHENSIVE LOSS

(14,823,535)

(7,151,955)

WEIGHTED AVERAGE NUMBER OF SHARES:

Basic

25,241,748

20,396,217

Diluted

25,241,748

20,396,217

LOSS PER SHARES:

Basic

$

(0.68)

$

(0.28)

Diluted

$

(0.68)

$

(0.28)

CHINA JO-JO DRUGSTORES, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY

Accumulated

Common Stock

Retained Earnings

other

Non-

Number of

Paid-in

Statutory

comprehensive

controlling

shares

Amount

capital

reserves

Unrestricted

income/(loss)

interest

Total

BALANCE,
March 31,
2016.

17,735,504

$

17,736

22,088,267

1,309,109

(6,957,053)

2,857,813

$

19,315,872

Stock based
    compensation

1,690,174

1,690

2,246,960

2,248,650

Net loss

(5,644,204)

(5,644,204)

Private direct
    offering
    financing

4,840,000

4,840

10,643,160

10,648,000

Issuance of
    common
    stocks in
    exchange
    of debts

949,000

949

1,602,821

1,603,810

Foreign
    currency
    translation
    loss

(1,507,751)

(1,507,751)

BALANCE,
    March 31,
    2017.

25,214,678

$

25,215

36,581,248

1,309,109

(12,601,257)

1,350,062

$

26,664,377

Stock based
    compensation

3,722,100

3,722

7,017,841

7,021,563

Net loss

(17,059,933)

(17,059,933)

Foreign
    currency
    translation
    loss

2,236,398

2,236,398

BALANCE,
    March 31,
    2018.

28,936,778

28,937

43,599,089

1,309,109

(29,661,190)

3,586,460

18,862,405

CHINA JO-JO DRUGSTORES, INC. AND SUBSIDIARIES

CONSOLIDATED STATEMENTS OF CASH FLOWS

For the years ended
March 31,

2018

2017

CASH FLOWS FROM OPERATING ACTIVITIES:

Net income

$

(17,059,933)

$

(5,644,204)

Adjustments to reconcile net income to net cash provided by operating activities:

Bad debt direct write-off and provision

4,009,636

679,271

Depreciation and amortization

1,383,810

1,316,747

Impairment of prepayment of lease use right

1,246,788

Farmland assets impairment

761,403

Impairment of land and road improvement

108,851

Impairment of leasehold improvement

1,583,186

Stock based compensation

7,021,563

2,248,650

Change in fair value of purchase option derivative liability

(357,421)

(140,084)

Change in operating assets:

Accounts receivable, trade

(2,072,486)

(717,386)

Notes receivable

(1,005)

(244,713)

Inventories and biological assets

(2,411,209)

191,564

Other receivables

(489,334)

(773,359)

Advances to suppliers

1,121,006

(3,020,156)

Long term deposit

15,103

Other current assets

(377,391)

(148,983)

Other noncurrent assets

36,091

35,509

Change in operating liabilities:

Accounts payable, trade

3,726,625

3,936,178

Other payables and accrued liabilities

1,115,267

1,250,755

Customer deposits

1,048,939

237,891

Taxes payable

(362,513)

234,780

Net cash provided by operating activities

(2,070,066)

1,559,502

CASH FLOWS FROM INVESTING ACTIVITIES:

Disposal of financial assets available for sale

445,968

Purchase of financial assets available for sale

(75,513)

(89,194)

Acquisition of equipment

(414,398)

(140,209)

Increase intangible assets

(1,140,102)

Termination of a joint venture

104,059

Investment in a joint venture

(96,180)

Additions to leasehold improvements

(1,347,489)

(270,990)

Net cash provided by (used in) investing activities

(2,977,502)

(46,546)

CASH FLOWS FROM FINANCING ACTIVITIES:

Repayment of short-term bank loan

(29,731)

Change in restricted cash

(5,664,224)

3,519,030

Proceeds from notes payable

27,461,423

24,577,096

Repayment of notes payable

(22,476,740)

(28,445,215)

Changes in other payables-related parties

375,659

Proceeds from sale of stock and warrants

10,648,000

Repayment of other payables-related parties

(91,395)

Net cash provided by (used in) financing activities

(770,936)

10,644,839

EFFECT OF EXCHANGE RATE ON CASH

2,586,720

(465,244)

(DECREASE) INCREASE IN CASH

(3,231,784)

11,692,551

CASH, beginning of year

18,364,424

6,671,873

CASH, end of year

$

15,132,640

$

18,364,424

SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:

Cash paid for interest

$

$

1,349

Cash paid for income taxes

$

27,825

$

57,247

Issuance of common stocks in exchange of debts

$

$

1,603,810

View original content:http://www.prnewswire.com/news-releases/china-jo-jo-drugstores-reports-fiscal-year-2018-financial-results-300674619.html

Source: China Jo-Jo Drugstores, Inc.

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